Arcturus Therapeutics

Arcturus therapeutics is a leading clinical-stage messenger RNA medicines company focused on the discovery, development and commercialization of therapeutics for rare diseases and vaccines. We have proprietary technologies, validating partnerships, and an experienced team with deep expertise in delivery and RNA-based therapeutics

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News & Events
May 8, 2013
Arcturus Therapeutics Announces New Appointments to its Board of Directors and Scientific Advisory Board
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June 1, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 3, 2013
With $1.3M in Seed Funding, Arcturus Adds to RNAi Hub in San Diego
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June 3, 2013
RNAi therapeutics startup sets up shop at Janssen labs, closes $1.3M seed round
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June 3, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 4, 2013
Janssen Labs-based Arcturus gets $1.3M boost for RNAi delivery tech
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June 4, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 4, 2013
Startup Arcturus Pulls in $1.3M in Seed Money amid Renewed Interest in RNAi
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August 14, 2013
Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina Biotech
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August 14, 2013
Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina
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August 15, 2013
San Diego upstart acquires RNA tech from cash-strapped Marina Biotech
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August 15, 2013
San Diego Life Sciences Roundup: Vical, Fate, Arcturus, and More
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August 15, 2013
Arcturus Therapeutics Acquires Patent Portfolio from Marina Biotech
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August 15, 2013
Marina Sells UNA Patent Estate to Arcturus as It Looks to Resume Operations
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October 21, 2013
GenomeWeb Acturus Closes $5M Series A Round, Aims for Clinic in '15 with RNAi Drug
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October 21, 2013
RNAi firm raises $5M to develop and deliver drugs that turn off disease-causing genes
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October 21, 2013
Arcturus Therapeutics Raises $5 Million in Series A Funding to Maintain its Momentum in Nominating Lead Clinical Candidate in 2014
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October 21, 2013
Arcturus Therapeutics Raises $5 Million in Series A Funding to Maintain its Momentum in Nominating Lead Clinical Candidate in 2014
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October 22, 2013
San Diego's Arcturus Raises $5M for 'Best-in-Class' RNAi Technology
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October 22, 2013
Arcturus Raises $5M in Series A Funding
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October 23, 2013
Arcturus rakes in $5M to back RNAi tech, nanoparticle delivery
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January 7, 2014
Arcturus Therapeutics, Inc. to Present at the Biotech Showcase 2014
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January 13, 2014
Arcturus Therapeutics, Inc. Announces an RNAi Therapeutic Targeting Transthyretin-mediated Amyloidosis as its Flagship Program
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January 13, 2014
Arcturus Therapeutics, Inc. Announces an RNAi Therapeutic Targeting Transthyretin-mediated Amyloidosis as its Flagship Program
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January 30, 2014
Arcturus Therapeutics to Present at the Keystone Symposia Conference on RNA Silencing
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February 24, 2014
Arcturus Therapeutics to Present RNAi Data for Orphan Diseases Utilizing the LUNARTM Technology Platform at BIOCOM's Global Life Science Partnering Conference
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February 27, 2014
Arcturus Releases Data Showing Potential of Delivery Technology for CRISPR Drugs
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March 10, 2014
Arcturus Therapeutics to Present at the BIO-Europe Spring Partnering Conference
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March 27, 2014
Arcturus Therapeutics to Present at the BioCentury Future Leaders in the Biotech Industry Conference
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April 7, 2014
Arcturus Therapeutics to Present at the 13th Annual Needham Healthcare Conference
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May 6, 2014
Arcturus Therapeutics Appoints Robert Baltera and Stuart Collinson, Ph.D. to its Board of Directors
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May 13, 2014
Arcturus Therapeutics Announces Allele-Specific Silencing Technology at IBC’s 16th Annual TIDES Conference
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June 23, 2014
Why San Diego is a Hub for RNA R&D and Drug Development
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October 13, 2014
Arcturus Therapeutics to Present Gene Knockdown Data in Non-Human Primates, Showing up to 94% Reduction in Gene Expression with a Single Low Dose
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October 16, 2014
Arcturus Touts Dosing, Specificity of ATTR Drugs as They Move Toward Clinic
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October 23, 2014
Top 30 Life Science Startups To Watch In The U.S.
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November 3, 2014
Arcturus Therapeutics expands in La Jolla
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November 3, 2014
Arcturus Therapeutics Expands Operations in San Diego, CA
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November 10, 2014
Arcturus Therapeutics Presents Preclinical Messenger RNA Data in Non-Human Primates at the 2nd International mRNA Health Conference
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November 11, 2014
Arcturus Demonstrates mRNA Delivery to Primates, Sees Possible Rx by 2016
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November 12, 2014
Arcturus Presents mRNA Delivery Data Applicable to CF Treatment
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November 20, 2014
Arcturus shoots for 'LUNAR' landing in treating rare diseases
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December 3, 2014
Arcturus Therapeutics to Present at the Genetic Rx Boston Biotech Conference
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December 9, 2014
Arcturus Therapeutics Announces the Appointment of Michael R. Hodges, M.D. to the Scientific Advisory Board
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January 7, 2015
Arcturus Therapeutics to Present Messenger RNA Pipeline at the 33rd Annual J.P. Morgan Healthcare Conference and the 7th Annual Biotech Showcase
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January 9, 2015
Precision NanoSystems and Arcturus Therapeutics Announce a Partnership for the Manufacture of RNA Medicines
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June 11, 2015
Arcturus Therapeutics Announces Strategic Collaboration with Johnson & Johnson Innovation to Discover and Develop RNA Medicines for Defined Indications
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October 11, 2015
2015 Oligonucleotide Therapeutics Society
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October 29, 2015
Ultragenyx gives Arcturus rocket shot in potential $1.57B deal
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October 29, 2015
Ultragenyx Pharmaceutical and Arcturus Therapeutics Announce a Research Collaboration and License Agreement to Develop RNA Therapeutics for Rare Diseases
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November 3, 2015
Arcturus Therapeutics Announces the Appointment of Drew Weissman M.D., Ph.D. to the Scientific Advisory Board
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November 11, 2015
International mRNA Health Conference
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January 6, 2016
Arcturus Therapeutics Selected to Present at Biotech Showcase™ 2016
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March 16, 2016
Arcturus Therapeutics Receives Intent to Grant Notice from the European Patent Office for their Unlocked Nucleomonomer Agent (UNA) Technology
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June 1, 2016
Arcturus Therapeutics To Present At 2016 BIO International Convention in San Francisco
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September 30, 2016
November 1-2, 2016
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October 3, 2016
Arcturus Therapeutics to Report Identification of LUNAR-HBV, a Potent Combination of Three UNA Oligomers Targeting All Hepatitis B Virus Genotypes at the AASLD Liver Meeting® 2016
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October 4, 2016
Big Pharma Goes Small With Moves Into Incubator Space
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November 1, 2016
nature Biotechnology and nature Reviews Drug Discovery
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December 6, 2016
Arcturus Therapeutics Announces Collaboration with Takeda Pharmaceuticals to Develop RNA–based Therapeutics for the Treatment of Nonalcoholic Steatohepatitis (NASH)
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January 7, 2017
East West CEO Conference-Panel Discussion on Mid-Cap Biotech: Challenges and Opportunities
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January 24, 2017
Fierce Innovation Awards 2016 Life Science Edition
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January 31, 2017
From Incubation to Investment: The Trajectory of Arcturus Therapeutics
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February 13, 2017
Arcturus Therapeutics to Present at the 19th Annual Bio CEO and Investor Conference in NY
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February 15, 2017
Collaboration between Salk institute (Verma lab) and Arcturus Therapeutics Inc. to treat hemophilia B in mice
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February 15, 2017
PNAS Publication on Arcturus and Salk--Systemic delivery of factor IX messenger RNA for protein replacement therapy
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February 24, 2017
Arcturus To Attend 8th Annual SBP Rare Disease Day Symposium: Alagille Syndrome - New Research, New Hope
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March 1, 2017
Arcturus To Attend Biocom Global Life Science Partnering Conference 2017
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March 3, 2017
Arcturus To present at UCSF Rare Disease Symposium: “A New Era of Nucleic Acid Therapeutics to Treat Orphan Diseases”.
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March 7, 2017
BioCentury featuring Arcturus Therapeutics in an article called Getting the Message
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March 9, 2017
Arcturus To Present at BD Boston Conference
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March 10, 2017
Arcturus Therapeutics featured by SCRIP Intelligence publication
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March 30, 2017
Arcturus to present at RNA & Oligonucleotide Therapeutics-Cold Spring Harbor Labratory
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April 3, 2017
Arcturus to present at the ACS 253rd National Meeting, on Potent delivery of LUNAR™ nanoparticles containing synthetic mRNA for therapeutic protein expression
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April 6, 2017
Melinda Richter, Head of Johnson & Johnson Innovation JLABS, highlighting Arcturus in the Nature Reviews Drug Discovery
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April 10, 2017
Arcturus Therapeutics is Selected by Ernst and Young as Semifinalists for the Entrepreneur Of The Year® 2017 Award in San Diego
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April 10, 2017
Arcturus Therapeutics is Selected by Ernst and Young as Semifinalists for the Entrepreneur Of The Year® 2017 Award in San Diego
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April 10, 2017
Arcturus Therapeutics is Selected by Ernst and Young as Semifinalists for the Entrepreneur Of The Year® 2017 Award in San Diego
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April 29, 2017
Arcturus Therapeutics to Present at the TIDES--Oligonucleotides and Peptide Therapeutics, on Unlocked Nucleomonomer Agent (UNA) Oligomer System, Challenges and Opportunities
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May 15, 2017
Ernst & Young Selected Arcturus as the Finalists for the Entrepreneur Of The Year 2017 Award® in San Diego
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May 29, 2017
Boston CEO Conference-Panel Discussion on Advances in Personalized Medicine
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May 29, 2017
Boston CEO Conference-Panel Discussion on Advances in Personalized Medicine
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June 1, 2017
GEN News Featuring Arcturus Therapeutics on its cover page--in Better Targeting, Delivery of RNAi Therapies
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June 16, 2017
Arcturus Therapeutics to Present at 2017 Bio International Convention (Mon June 19th)
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June 20, 2017
Xconomy article on Arcturus Therapeutics, Inc.
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June 22, 2017
GEN article on Arcturus Therapeutics Inc.
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July 6, 2017
Union Tribune article on Arcturus Therapeutics Inc.
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July 7, 2017
The Korea Herald News on Arcturus Therapeutics Inc.
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July 13, 2017
Arcturus Therapeutics Inc. is Listed in the Key Players List; Involved in Non Alcoholic Steatohepatitis Pipeline (NASH)
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August 9, 2017
Arcturus Therapeutics in the list of Cystic Fibrosis Key Companies
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August 23, 2017
Pictures by Ernst and Young (Finalists for the Entrepreneur Of The Year 2017 Award® in San Diego)
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May 30, 2017
Arcturus Therapeutics to Receive Up to $3 Million from Cystic Fibrosis Foundation Therapeutics to Advance a Novel LUNAR-Formulated mRNA CFTR Therapeutic
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September 27, 2017
Alcobra Ltd. and Arcturus Therapeutics, Inc. Agree to Merge
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September 27, 2017
Webcast: Arcturus Merger w/Alcobra Conference Call
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October 6, 2017
Arcturus Therapeutics, Inc. to Present at the Chardan Gene Therapy Conference
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October 19, 2017
Arcturus Therapeutics Announces Strategic Collaboration with Johnson & Johnson Innovation to Discover and Develop RNA Medicines
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October 26, 2017
Arcturus Therapeutics Announces Presentations at Conferences in November
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October 30, 2017
Arcturus Therapeutics to Present at the 5th International mRNA Health Conference on Nov 1st
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October 30, 2017
Arcturus Therapeutics to Present at the 2017 North American Cystic Fibrosis Conference on Nov 2nd
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October 30, 2017
Arcturus Therapeutics to Present at NY/NJ CEO Conference on Nov 8th
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October 31, 2017
Arcturus Therapeutics and Synthetic Genomics Announce Strategic Alliance to Develop Next-Generation Vaccines and Therapeutics
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November 2, 2017
Arcturus Therapeutics to Host Key Opinion Leader Call on Advances in Delivery of Nucleic Acid Medicines on Tuesday, November 7
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November 16, 2017
Arcturus Therapeutics Announces Completion of Merger with Alcobra Ltd. and Commences Trading on the Nasdaq Global Market
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November 16, 2017
Arcturus Therapeutics Announces Completion of Merger with Alcobra Ltd. and Commences Trading on the Nasdaq Global Market
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December 6, 2017
Arcturus Therapeutics Ltd., to Present at Genetic Rx Conference at Harvard Medical School (Dec 7th), in a Panel Discussion Called “Next Generation RNA Technologies”
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May 29, 2018
Arcturus Therapeutics Appoints Four New Directors and Reaches Settlement Agreement with Founder Joseph E. Payne
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May 30, 2018
Arcturus Therapeutics Announces Extraordinary General Meeting of Shareholders
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May 31, 2018
Arcturus Announces Management Appointments; Company Founder Joseph E. Payne Reinstated as President and CEO
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June 18, 2018
Arcturus Therapeutics to Present at the JMP Securities Life Sciences Conference
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July 9, 2018
Arcturus Therapeutics Announces Results of Extraordinary General Meeting of Shareholders
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July 20, 2018
Arcturus Therapeutics Announces Annual and Extraordinary General Meeting of Shareholders to Be Held on August 24, 2018
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July 23, 2018
Arcturus Therapeutics Achieves Program Milestones and Refines Agreement with Cystic Fibrosis Foundation Therapeutics
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August 27, 2018
Arcturus Therapeutics to Present at Three Investor Conferences in September
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August 28, 2018
Arcturus Therapeutics Appoints Andrew Sassine as Interim Chief Financial Officer
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August 29, 2018
Arcturus Therapeutics Announces Appointment of Ernst & Young LLP as the Company’s Independent Auditor
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September 21, 2018
Arcturus Therapeutics Expands Management Team
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September 25, 2018
Arcturus Therapeutics to Present at October Investor Conferences
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October 1, 2018
Arcturus Therapeutics Reports Second Quarter 2018 Financial Results and Provides Corporate Update
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November 5, 2018
Arcturus Therapeutics Hosts Ribbon Cutting Ceremony for its Research and Development Facility
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November 7, 2018
Arcturus Therapeutics Provides Corporate Update and Reports Third Quarter 2018 Financial Results
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December 3, 2018
Arcturus Therapeutics to Host a Key Opinion Leader Call on Ornithine Transcarbamylase (OTC) Deficiency on December 11
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January 2, 2019
Arcturus Therapeutics to Develop ARCT-810 for Treatment of Ornithine Transcarbamylase (OTC) Deficiency
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January 3, 2019
Arcturus Therapeutics Appoints Andrew Sassine as Chief Financial Officer
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February 11, 2019
Arcturus Therapeutics Reassumes Full Worldwide Rights to ARCT-810, a Clinical Development Candidate for Ornithine Transcarbamylase (OTC) Deficiency
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February 11, 2019
Arcturus Therapeutics to Present at Upcoming Investor Conferences
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March 18, 2019
Arcturus Therapeutics Provides Corporate Update and Reports Fourth Quarter and Year End 2018 Financial Results
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May 20, 2019
Arcturus Therapeutics Presenting Data for ARCT-810 and the Arcturus mRNA + LUNAR® Technology Platform at the 2019 Annual Meeting of TIDES: Oligonucleotide and Peptide Therapeutics
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June 13, 2019
Arcturus Therapeutics Announces Redomiciliation to the United States as a Delaware Corporation
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June 19, 2019
Ultragenyx and Arcturus Therapeutics Expand Existing Research Collaboration and License Agreement to Develop Additional Nucleic Acid Therapies for Rare Diseases
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June 27, 2019
Arcturus Therapeutics Receives Orphan Drug Designation from the U.S. FDA for ARCT-810, for Treatment of Ornithine Transcarbamylase (OTC) Deficiency
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July 10, 2019
Arcturus Therapeutics to Participate in Two Panels at the ROTH RNA Revolution Conference
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August 1, 2019
Arcturus Therapeutics Receives up to $15 Million Commitment from the Cystic Fibrosis Foundation to Create mRNA Therapies to Treat Cystic Fibrosis Patients
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August 1, 2019
Arcturus Therapeutics Announces $10.9 Million Registered Direct Offering of Common Stock
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August 2, 2019
Arcturus Therapeutics Announces $2.3 Million Additional Registered Direct Offering of Common Stock
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August 7, 2019
Arcturus to Report Corporate Overview and Financial Results on August 15
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August 15, 2019
Arcturus Therapeutics Announces Second Quarter Financial Results and Provides a Corporate Update
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August 26, 2019
Arcturus Therapeutics To Present at Two Investor Conferences in September
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September 23, 2019
Arcturus Therapeutics Announces Appointment of Dr. Edward Holmes M.D. and Re-Appointment of Andy Sassine to the Board of Directors
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September 26, 2019
Arcturus Therapeutics Announces $9.8 Million Registered Direct Offering of Common Stock
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October 2, 2019
Arcturus Therapeutics to Present at Three Upcoming Investor Conferences
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November 4, 2019
Arcturus Therapeutics to Report Corporate Overview and Financial Results on November 7th
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November 7, 2019
Arcturus Therapeutics Expands Platform with STARR™ Technology
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November 7, 2019
Arcturus Therapeutics Announces Third Quarter Financial Results and Provides Corporate Update
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January 8, 2020
Arcturus Therapeutics Appoints Steve Hughes, M.D., as Chief Development Officer
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February 19, 2020
Arcturus Therapeutics to Present at Two Investor Conferences in March
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February 25, 2020
Arcturus Therapeutics to Report Fourth Quarter and Year-End 2019 Financial Results and Provide Corporate Update on March 11
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March 4, 2020
Arcturus Therapeutics and Duke-NUS Medical School Partner to Develop a Coronavirus (COVID-19) Vaccine using STARR™ Technology
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March 27, 2020
Arcturus COVID-19 Vaccine to Benefit from Duke-NUS Genetic Correlation System
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April 9, 2020
Arcturus Therapeutics Announces Clinical Trial Timeline for its COVID-19 Vaccine
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April 13, 2020
Arcturus Therapeutics Announces Allowance of IND & Approval of Clinical Trial Application (CTA) for ARCT-810, a First-in-Class Investigational mRNA Medicine to Treat Ornithine Transcarbamylase Deficiency
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April 15, 2020
Arcturus Therapeutics Announces Proposed Public Offering of Common Stock
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April 16, 2020
Arcturus Therapeutics Announces Pricing of $70.0 Million Public Offering of Common Stock
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April 20, 2020
Arcturus Therapeutics and Duke-NUS Medical School Partner to Develop a Coronavirus (COVID-19) Vaccine using STARR™ Technology
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April 21, 2020
Arcturus Therapeutics Announces Closing of Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares
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April 27, 2020
Arcturus Reports Positive Preclinical Data for its COVID-19 Vaccine Candidate
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May 4, 2020
Arcturus Therapeutics and Catalent Announce Partnership to Manufacture mRNA-Based COVID-19 Vaccine
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May 5, 2020
Arcturus Therapeutics to Report First Quarter 2020 Financial Results and Provide a Corporate Update on May 7, 2020
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May 7, 2020
Arcturus Therapeutics Announces First Quarter 2020 Financial Results and Provides a Corporate Update
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May 8, 2020
Arcturus Reports Additional Supportive Preclinical Data for its COVID-19 Vaccine Candidate (LUNAR-COV19)
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May 21, 2020
Ultragenyx Announces Exercise of Option to Purchase Additional Stock of Arcturus Therapeutics
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June 5, 2020
Arcturus Therapeutics Announces First Healthy Volunteer Dosed in Phase 1 Study of ARCT-810 for Ornithine Transcarbamylase (OTC) Deficiency
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June 11, 2020
Arcturus Therapeutics to Present at the Raymond James Human Health Innovation Virtual Conference
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June 29, 2020
Arcturus Therapeutics to be Added to Russell 2000® Index
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July 1, 2020
Arcturus Therapeutics Announces the Formation of its Vaccine Platform Scientific Advisory Board
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July 21, 2020
Arcturus Therapeutics & Duke-NUS Received Approval to Proceed with Phase 1/2 Clinical Trial for COVID-19 Vaccine Candidate, LUNAR-COV19
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July 23, 2020
Arcturus Therapeutics Announces Agreement with Israeli Ministry of Health to Supply COVID-19 Vaccine Candidate, LUNAR-COV19
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July 28, 2020
Arcturus Therapeutics Announces Proposed Public Offering of Common Stock
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July 29, 2020
Arcturus Therapeutics Announces Pricing of $173.0 Million Public Offering of Common Stock
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August 4, 2020
Arcturus Therapeutics to Report Second Quarter 2020 Financial Results and Provide Corporate Update on August 10, 2020
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August 6, 2020
Arcturus Therapeutics Appoints Lance Kurata as Chief Legal Officer
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August 10, 2020
Arcturus Therapeutics Announces Second Quarter 2020 Financial Results and Provides a Corporate Update
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August 11, 2020
Arcturus Therapeutics Announces that it has Initiated Dosing of its COVID-19 STARR™ mRNA Vaccine Candidate, LUNAR-COV19 (ARCT-021) in a Phase 1/2 study
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August 18, 2020
Arcturus Therapeutics Executes Definitive Supply Agreement with the Israeli Ministry of Health
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September 4, 2020
Arcturus Therapeutics Announces Preclinical Publication of its COVID-19 Vaccine Candidate
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September 8, 2020
Arcturus Therapeutics to Present at Upcoming Investor and Scientific Conferences
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October 1, 2020
Arcturus Therapeutics to Present at Guggenheim’s Vaccines and Infectious Diseases Conference
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October 5, 2020
Arcturus Therapeutics Announces Completion of First Three Dose Escalation Cohorts in Phase 1 Study of ARCT-810, Therapeutic Candidate for Ornithine Transcarbamylase (OTC) Deficiency
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October 6, 2020
Recipharm signs agreement with Arcturus Therapeutics to support the manufacture of LUNAR®-COV19 (ARCT-021) vaccine candidate
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October 30, 2020
Arcturus Therapeutics to Report Third Quarter 2020 Financial Results and Provide Corporate Update on Nov 9, 2020
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November 4, 2020
Arcturus Therapeutics to Present at Upcoming Investor and Scientific Conferences
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November 9, 2020
Arcturus Therapeutics Announces Positive Interim ARCT-021 (LUNAR-COV19) Phase 1/2 Study Results for Both Single Shot and Prime-boost Regimens, and Up to $220 Million in Additional Financial Commitments from Singapore
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November 9, 2020
Arcturus Therapeutics Announces Third Quarter 2020 Financial Results and Positive Clinical Updates for ARCT-810 Phase I Study and Additional ARCT-021 Interim Data
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LUNAR®-mediated delivery of RNA into cells

LUNAR® particles associate with the cell membrane of a target cell of interest and quickly enter the cell via endocytosis.

Upon entering the cytosol, the LUNAR® formulations then become trapped in the endosomes.

With increased acidity as the endosome ages, a pH-mediated disruption enables release of the RNA payload following rapid biodegradation of the LUNAR®components.

Once release of the RNA into the cytosol occurs, the translational machinery can interact with the RNA and processing and/or trafficking can then take place to make functional protein.

LUNAR® lipid mediated delivery enables delivery of RNA medicines.