Arcturus Therapeutics

Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is an RNA medicines company with enabling technologies – LUNAR® lipid-mediated delivery, Unlocked Nucleomonomer Analog (UNA) chemistry, STARR™ technology – and mRNA drug substance along with drug product manufacturing. Arcturus’ diverse pipeline of RNA therapeutics includes programs to potentially treat Ornithine Transcarbamylase (OTC) Deficiency, Cystic Fibrosis, Glycogen Storage Disease Type 3, Hepatitis B, and non-alcoholic steatohepatitis (NASH). Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus’ technologies are covered by its extensive patent portfolio (182 patents and patent applications, issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, CureVac AG, Synthetic Genomics Inc. and the Cystic Fibrosis Foundation. For more information visit www.Arcturusrx.com

Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients. Please email your resume to Careers@ArcturusRx.com

Director of Analytical Development and Quality Control

POSITION SUMMARY: 

Arcturus is seeking a Director to lead method development and quality control for mRNA characterization and release. A successful candidate in this role will be responsible for leading analytical method development, validation, test method transfers to QC labs, initiation on internal QC testing at Arcturus, and stability evaluations.  The candidate will also support quality and regulatory teams to provide relevant documentation and draft sections of regulatory filings. The candidate will be required to resolve complex method development challenges through collaboration with the process development, manufacturing and analytical teams. They will work closely with a team of highly motivated scientists and engineers in the RNA process development and analytical sciences group to enable successful GMP manufacture and release of mRNA therapeutics and vaccines.

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Research Associate II, Analytical method development, RNA Sciences

POSITION SUMMARY:

Arcturus is seeking Research Associate II to work in the Analytical method development department of the RNA Sciences team.  A successful candidate in this role will be responsible for carrying out required analytical lab activities for mRNA targets including: RP-HPLC, Electrophoresis (gel, capillary, Fragment analyzer, bioanalyzer), Spectroscopic (UV-vis, luminescence, absorbance, fluorescence methodologies), Antibody-based detection methods (ELISA, Western blots, WES/JESS), Gene amplification methods (PCR, RT-qPCR, Quantigene) and Enzyme-based methods (reaction kinetics and end point assays). Additionally, they will be responsible for preparing detailed documentation for method transfer.  They will support project leads, key internal and external stakeholders, and Arcturus’ research leadership to advance development projects.

 

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Clinical Trial Manager

Position Summary:

This position will be responsible for the operational management and the oversight of clinical trials within a clinical development program.  This individual will be responsible for the successful execution of clinical trials from the protocol concept through the clinical study report, ensuring completion of study deliverables, providing oversight of the CRO and other third party vendors on assigned study. The Clinical Trial Manager will work closely with a Project Leader, or Pharmacovigilance, Regulatory, etc., and will report into the Clinical Operations Manager.

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Research Associate / Senior Research Associate, Drug Discovery

Position Summary:

We are looking for a Research Associate / Senior Research Associate to join our growing team. The Research Associate will conduct hands-on experiments in the Drug Discovery department with a wide variety of cellular biology, molecular biology, and biochemistry techniques. This person will be expected to complete scientific and technical tasks on aggressive timelines and to work as part of a team on varied projects with changing priorities. This position requires excellent communication skills, an outstanding ability to troubleshoot technical issues, a superior ability to plan and carry out experiments independently, and to work with complex instrumentation and software. Exact title and responsibilities will be commensurate with experience.

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Scientist I/II, Translational Biology (In Vivo)

Position Summary:

We are seeking an experienced in vivo pharmacology scientist to support preclinical stage programs through the management, design, planning, and execution of in vivo studies.

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Bioanalytical Scientist

Position Summary:

Arcturus Therapeutics is seeking an innovative, highly motivated, experienced, resourceful, hands-on individual to join our expanding preclinical team in the role of Senior Scientist, Bioanalytical. The scientist will The successful candidate must have scientific knowledge and technical experience in developing, troubleshooting, transferring, optimizing, and validating PK, ADA, and Biomarker assays for biotherapeutics in biological matrices.

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Senior Clinical Trial Manager

Position Summary:

The Senior Clinical Trial Manager provides clinical trial oversight to the assigned clinical trial ensuring deliverables are met in terms of quality, compliance, and timing. Strong vendor management is critical for this role: external vendors (including bioanalytical and safety laboratories, drug depots, and full-service CROs. The position reports to the Chief Development Officer and is accountable to the Clinical Operations Lead for assigned studies. This role may work collaboratively on one trial or across several trials to support clinical operations activities.

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Accounts Payable Specialist (Biotech)

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Program Manager (Clinical – Vaccines)

Position Summary:

This role is a key position within Arcturus’ Global Program Management Office and will be responsible for supporting the advancement of one or more clinical-stage programs. The successful candidate will be an experienced and self-motivated Program Manager responsible for the management of development timelines and deliverables with a clear understanding of functional interdependencies and critical path activities. The ideal candidate would be highly adaptable and proactive problem-solver who is highly knowledgeable of the processes involved in clinical studies.

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Senior Research Associate/Scientist I, Translational Biology

Position Summary:

Arcturus is seeking a highly motivated and skilled cell biologist with a proven track record of scientific accomplishment and technical expertise. This position requires an excellent ability to develop and optimize in vitro assays and troubleshoot technical challenges in an innovative and timely manner. Applicants should have extensive laboratory research experience and a desire to continue conducting experiments independently with a high level of vigor and quality

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Director/Senior Director BA

Position Summary:

Arcturus Therapeutics is seeking an innovative, highly motivated, experienced, resourceful, hands-on individual to lead the Bioanalytical team in the role of Director/Senior Director, Bioanalytical.  The individual will oversee the regulated bioanalytical PK, ADA, and Biomarker assay development and execution in support of nonclinical safety and clinical studies.  The individual will also be responsible for the management of the platform bioanalytical screening team supporting research.  The individual will lead and build out the bioanalytical department to support the expanding nonclinical and clinical development needs of Arcturus.

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Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Arcturus Therapeutics. To protect the interest of all parties involved, we will only accept resumes from a recruiter if an executed search agreement is in place at the start of the recruitment effort. Unsolicited resumes sent to Arcturus Therapeutics from recruiters do not constitute any type of relationship between the recruiter and Arcturus Therapeutics and do not obligate Arcturus Therapeutics to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.

We thank all applicants for their interest. However, due to the volume of applications we receive, only shortlisted applicants will be contacted.