Arcturus’ unlocked nucleomonomer agents (UNAs) can improve the in vivo efficiency of small interfering RNA (siRNA)-mediated gene silencing and potentially improve the efficiency of messenger RNA (mRNA)-mediated protein replacement. UNAs are RNA analogues in which the C2′-C3′ bond of the ribose ring is absent (see figure below).
One or more UNAs can be positioned strategically along a nucleic acid strand to manipulate the chemical properties of the molecule. Addition of a single UNA in siRNA therapeutics can enable more efficient suppression of target protein production.
September 21, 2018
Arcturus Therapeutics Expands Management Team
August 29, 2018
Arcturus Therapeutics Announces Appointment of Ernst & Young LLP as the Company’s Independent Auditor
August 28, 2018
Arcturus Therapeutics Appoints Andrew Sassine as Interim Chief Financial Officer