Arcturus' RNA & mRNA Proprietary Technologies

Technologies

We believe our two proprietary technologies, LUNAR® lipid-mediated delivery and STARR™ mRNA Technology, solve major hurdles in RNA medicine development.

LUNAR®

Our first platform is a proprietary lipid-mediated nucleic acid delivery system called LUNAR®. LUNAR® is a multi-component drug delivery system that is versatile and with our library of over 250 proprietary lipids, diverse. Our preclinical studies have shown that formulations can be customized for the indication and target cell type of interest. We have also demonstrated that our formulation process is scalable and reproducible.

LUNAR® Mechanism of Delivery Video

STARR

The STARR Technology platform combines self-replicating RNA with LUNAR®, a leading nanoparticle delivery system, into a single solution to produce proteins inside the human body. The versatility of the STARR Technology enables it upon delivery into the cell to generate a protective immune response or drive therapeutic protein expression to potentially prevent against or treat a variety of diseases. The self-replicating RNA-based prophylactic vaccine triggers rapid and prolonged antigen expression within host cells resulting in protective immunity against infectious pathogens. This combination of the LUNAR® and STARR technology is expected to provide lower dose requirements due to superior immune response, sustained protein expression compared to non-self-replicating RNA-based vaccines and potentially enabling to produce vaccines more quickly and simply.

COVID-19 Vaccine Using STARR mRNA Technology

LUNAR®-mediated delivery of RNA into cells

LUNAR® particles associate with the cell membrane of a target cell of interest and quickly enter the cell via endocytosis.

Upon entering the cytosol, the LUNAR® formulations then become trapped in the endosomes.

With increased acidity as the endosome ages, a pH-mediated disruption enables release of the RNA payload following rapid biodegradation of the LUNAR®components.

Once release of the RNA into the cytosol occurs, the translational machinery can interact with the RNA and processing and/or trafficking can then take place to make functional protein.

News & Events
March 4, 2013
Arcturus Therapeutics Begins Operations in Janssen Labs
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May 8, 2013
Arcturus Therapeutics Announces New Appointments to its Board of Directors and Scientific Advisory Board
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September 27, 2022
Arcturus Therapeutics to Attend the Following Investor Conferences
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October 26, 2022
Arcturus Therapeutics to Report Third Quarter 2022 Financial Results and Provide Corporate Update on November 9, 2022
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November 1, 2022
Arcturus Announces Collaboration with CSL to Develop and Commercialize Self-amplifying mRNA Vaccines
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November 8, 2022
Arcturus Therapeutics to Present at the Following Investor Conferences in November
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November 9, 2022
Arcturus Therapeutics Announces Third Quarter 2022 Financial Update and Pipeline Progress
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December 12, 2022
CSL Announces Closing of Global Collaboration and Licensing Agreement with Arcturus Therapeutics
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December 13, 2022
Arcturus Appoints John Markels, Ph.D. to its Board of Directors
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December 19, 2022
Arcturus Therapeutics to Present at the 41st Annual J.P. Morgan Healthcare Conference
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January 31, 2023
Arcturus Therapeutics Announces Clinical Trial Application for ARCT-032 Received Approval to Proceed into First-in-Human Studies to Treat Cystic Fibrosis
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March 28, 2023
Arcturus Therapeutics Announces Fourth Quarter 2022 Financial Update and Pipeline Progress
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April 26, 2023
Arcturus Therapeutics to Report First Quarter Financial Results and Provide Corporate Update on May 9, 2023
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May 9, 2023
Arcturus Therapeutics Announces First Quarter 2023 Financial Update and Pipeline Progress
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June 1, 2023
Arcturus Therapeutics Receives U.S. FDA Fast Track Designation for ARCT-810, mRNA Therapeutic Candidate for Ornithine Transcarbamylase Deficiency
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July 24, 2023
Arcturus Therapeutics to Report Second Quarter 2023 Financial Results and Provide Corporate Update on August 7, 2023
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August 7, 2023
Arcturus Therapeutics Announces Second Quarter 2023 Financial Update and Pipeline Progress
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August 14, 2023
Arcturus Therapeutics Joint Venture mRNA Manufacturing Partner, ARCALIS, Awarded $115 Million in Grants from the Japanese Government
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August 17, 2023
Arcturus Therapeutics to Attend Upcoming Investor Conferences
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September 5, 2023
Arcturus Therapeutics and CSL Announce European Medicines Agency Validates Marketing Authorization Application for ARCT-154 Vaccine to Prevent COVID-19
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September 19, 2023
Study Shows Novel sa-mRNA Vaccines Offer Robust, Broad, Enduring Protection Against COVID-19 Variants
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September 26, 2023
Arcturus Therapeutics and Cystic Fibrosis Foundation Extend Agreement to Advance ARCT-032, an Investigational Messenger RNA (mRNA) Therapeutic to Treat Cystic Fibrosis
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