Arcturus' RNA & mRNA Proprietary Technologies

Technologies

We believe our two proprietary technologies, LUNAR® lipid-mediated delivery and STARR® mRNA Technology, solve major hurdles in RNA medicine development.

LUNAR®

Our first platform is a proprietary lipid-mediated nucleic acid delivery system called LUNAR®. LUNAR® is a multi-component drug delivery system that is versatile and with our library of over 250 proprietary lipids, diverse. Our preclinical studies have shown that formulations can be customized for the indication and target cell type of interest. We have also demonstrated that our formulation process is scalable and reproducible.

LUNAR® Mechanism of Delivery Video

STARR®

The STARR® Technology platform combines self-replicating RNA with LUNAR®, a leading nanoparticle delivery system, into a single solution to produce proteins inside the human body. The versatility of the STARR® Technology enables it upon delivery into the cell to generate a protective immune response or drive therapeutic protein expression to potentially prevent against or treat a variety of diseases. The self-replicating RNA-based prophylactic vaccine triggers rapid and prolonged antigen expression within host cells resulting in protective immunity against infectious pathogens. This combination of the LUNAR® and STARR® technology is expected to provide lower dose requirements due to superior immune response, sustained protein expression compared to non-self-replicating RNA-based vaccines and potentially enabling to produce vaccines more quickly and simply.

COVID-19 Vaccine Using STARR® mRNA Technology

LUNAR®-mediated delivery of RNA into cells

LUNAR® particles associate with the cell membrane of a target cell of interest and quickly enter the cell via endocytosis.

Upon entering the cytosol, the LUNAR® formulations then become trapped in the endosomes.

With increased acidity as the endosome ages, a pH-mediated disruption enables release of the RNA payload following rapid biodegradation of the LUNAR®components.

Once release of the RNA into the cytosol occurs, the translational machinery can interact with the RNA and processing and/or trafficking can then take place to make functional protein.

News & Events
March 4, 2013
Arcturus Therapeutics Begins Operations in Janssen Labs
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May 8, 2013
Arcturus Therapeutics Announces New Appointments to its Board of Directors and Scientific Advisory Board
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June 1, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 3, 2013
With $1.3M in Seed Funding, Arcturus Adds to RNAi Hub in San Diego
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June 3, 2013
RNAi therapeutics startup sets up shop at Janssen labs, closes $1.3M seed round
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June 3, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 4, 2013
Janssen Labs-based Arcturus gets $1.3M boost for RNAi delivery tech
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June 4, 2013
Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding
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June 4, 2013
Startup Arcturus Pulls in $1.3M in Seed Money amid Renewed Interest in RNAi
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August 14, 2013
Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina Biotech
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August 14, 2013
Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina
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August 15, 2013
San Diego upstart acquires RNA tech from cash-strapped Marina Biotech
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August 15, 2013
San Diego Life Sciences Roundup: Vical, Fate, Arcturus, and More
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August 15, 2013
Arcturus Therapeutics Acquires Patent Portfolio from Marina Biotech
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August 15, 2013
Marina Sells UNA Patent Estate to Arcturus as It Looks to Resume Operations
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October 21, 2013
GenomeWeb Acturus Closes $5M Series A Round, Aims for Clinic in '15 with RNAi Drug
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October 21, 2013
RNAi firm raises $5M to develop and deliver drugs that turn off disease-causing genes
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October 21, 2013
Arcturus Therapeutics Raises $5 Million in Series A Funding to Maintain its Momentum in Nominating Lead Clinical Candidate in 2014
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October 21, 2013
Arcturus Therapeutics Raises $5 Million in Series A Funding to Maintain its Momentum in Nominating Lead Clinical Candidate in 2014
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September 5, 2023
Arcturus Therapeutics and CSL Announce European Medicines Agency Validates Marketing Authorization Application for ARCT-154 Vaccine to Prevent COVID-19
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September 19, 2023
Study Shows Novel sa-mRNA Vaccines Offer Robust, Broad, Enduring Protection Against COVID-19 Variants
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September 26, 2023
Arcturus Therapeutics and Cystic Fibrosis Foundation Extend Agreement to Advance ARCT-032, an Investigational Messenger RNA (mRNA) Therapeutic to Treat Cystic Fibrosis
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October 4, 2023
Arcturus Therapeutics Joint Venture mRNA Manufacturing Partner, ARCALIS, Awarded Additional Financial Grants from Japanese Government
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October 23, 2023
Arcturus Therapeutics to Attend Upcoming Investor & Scientific Conferences
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October 25, 2023
Arcturus Therapeutics to Report Third Quarter Financial Results and Provide Corporate Update on November 14, 2023
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November 14, 2023
Arcturus Therapeutics Announces Third Quarter 2023 Financial Update and Pipeline Progress
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November 27, 2023
Arcturus Therapeutics Receives Orphan Drug Designation from the U.S. FDA for ARCT-032, for the Treatment of Cystic Fibrosis
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November 28, 2023
Japan's Ministry of Health, Labour and Welfare Approves CSL and Arcturus Therapeutics’ ARCT-154, the First Self-Amplifying mRNA Vaccine Approved for COVID in Adults
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December 4, 2023
Arcturus Therapeutics to Present at the 42nd Annual J.P. Morgan Healthcare Conference
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December 21, 2023
CSL and Arcturus Therapeutics’ ARCT-154 Demonstrates Non-Inferiority to Original Strain and Superior Immunogenicity to Omicron BA.4/5 Variant Compared to First-Generation mRNA Vaccine Booster
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February 5, 2024
New COVID-19 sa-mRNA Results from CSL and Arcturus Therapeutics Demonstrate Longer Duration of Immunity Compared to Conventional COVID-19 mRNA Vaccine Booster
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February 20, 2024
Arcturus Therapeutics to Report Fourth Quarter and Full Year 2023 Financial Results and Provide Corporate Update on March 7, 2024
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February 22, 2024
Arcturus Therapeutics Receives Orphan Medicinal Product Designation from the European Commission (EC), for ARCT-032, for the Treatment of Cystic Fibrosis
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February 26, 2024
Arcturus Therapeutics to Present at the Barclays 26th Annual Global Healthcare Conference
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March 7, 2024
Arcturus Therapeutics Announces Fourth Quarter and Fiscal Year 2023 Financial Update and Pipeline Progress
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April 25, 2024
Arcturus Therapeutics to Report First Quarter Financial Results and Provide Corporate Update on May 8, 2024
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May 8, 2024
Arcturus Therapeutics Announces First Quarter 2024 Financial Update and Pipeline Progress
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May 15, 2024
Arcturus Therapeutics to Attend Upcoming Investor & Scientific Conferences
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May 20, 2024
Nature Communications Publishes Pivotal Data Demonstrating Efficacy and Tolerability of CSL and Arcturus Therapeutics’ COVID-19 Vaccine
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